反应详情

A 2 liter reactor equipped with mechanical stirrer, thermometer and condenser was loaded with 600 ml of water, 110 g of 2-amino-4,5,6,7-tetrahydro-benzothiazole-6-carboxylic acid ethyl ester hydrobromide [(III), R1=ethyl] and 120 ml of methanol. The mixture was refluxed and hot filtered on a Celite bed. The resulting solution was added with a solution of 32 g of sodium bicarbonate in 300 ml of water (final pH=7-8). After 2 hours at room temperature, the precipitated white solid was filtered, washed with 100 ml of water and dried to obtain 72 g of the title product.

1. customA 2 liter reactor equipped with mechanical stirrer
2. temperatureThe mixture was refluxed
3. filtrationhot filtered on a Celite bed
4. additionThe resulting solution was added with a solution of 32 g of sodium bicarbonate in 300 ml of water (final pH=7-8)
5. filtrationthe precipitated white solid was filtered
6. washwashed with 100 ml of water
7. customdried