HCID 90039622, compound → HCID 90039274, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(4-tert-butyl-phenylethynyl)-isonicotinic acid methyl ester (786 mg, 2.68 mmol) and polyphosphoric acid (10 g) is heated to 80° C. and stirred at this temperature for three days. The reaction mixture is allowed to cool to room temperature and water is added. The resulting precipitate is filtered off, washed with water and dried under vacuum to afford 3-(4-tert-butyl-phenyl)-pyrano[4,3-c]pyridin-1-one as olive green powder; HPLC/MS 2.16 min (A), [M+H] 280;

Provenance & Evidence