HCID 14088833, compound → HCID 10494494, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(4-bromo-phenylethynyl)-benzoic acid methyl ester (1.24 g, 3.95 mmol) and polyphosphoric acid (16 g) is heated to 80° C. and stirred at this temperature for 20 hours. The reaction mixture is allowed to cool to room temperature and water is added. The resulting precipitate is filtered off, washed with water and dried under vacuum to afford 3-(4-bromo-phenyl)-isochromen-1-one as brown powder; HPLC/MS 2.18 min (A), [M+H] 301/303.

Provenance & Evidence