Hydrochloric Acid → HCID 73057458, compound

Participants

Reaction Steps

Under nitrogen, lithium aluminiumhydride (22.8 mg, 0.60 mmol) is added to a suspension of 4-(1-oxo-1,2-dihydro-isoquinolin-3-yl)-benzoic acid methyl ester (83.8 mg, 0.301 mmol) (for preparation see previous example) in THF (3 ml). The reaction mixture is stirred at ambient temperature for 16 hours. A few drops of methanol and then HCl (2 N aqueous solution, 0.5 ml) are added slowly to the reaction mixture. It is then filtered over a pad of celite. The filtrate is evaporated and the residue is triturated with tert-butyl methylether to afford 3-(4-hydroxymethyl-phenyl)-2H-isoquinolin-1-one as brown powder; HPLC/MS 1.55 min (A), [M+H] 252;

Provenance & Evidence