Potassium Carbonate → HCID 178525750, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of trans-4-aminocyclohexanecarboxylic acid hydrochloride (2.00 g, 11.1 mmol), 5-bromo-2-fluoropyridine (2.29 mL, 22.3 mmol), potassium carbonate (3.08 g, 22.3 mmol), DIEA (3.89 mL, 22.3 mmol) in NMP (50 mL) was heated to 130° C. overnight. The reaction was cooled to room temperature, filtered through a pad of CELITE, and washed with NMP (50 mL). The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel chromatography (CH2Cl2/MeOH, 0-10%) to afford trans-4-[(5-bromopyridin-2-yl)amino]cyclohexanecarboxylic acid as a off-white solid. MS ESI calc'd for C12H16BrN2O2 [M+H]+ 299 and 301. found 299 and 301.

Provenance & Evidence