Hydrochloric Acid → HCID 118092787, compound

Participants

Reaction Steps

tert-Butyl 2-(5-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)pyridin-2-yl)acetate (25 mg, 0.056 mmol) was added to HCl in dioxane (0.5 ml, 2.000 mmol, 4M). The mixture was stirred at room temperature for 1 hour. The solid was collected by the filtration and afforded 2-(5-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)pyridin-2-yl)acetic acid (14.1 mg, 0.033 mmol). MS ESI calc'd. for C19H16F3N4O2 [M+H]+ 389. found 389. 1H NMR (500 MHz, CD3OD): δ 9.07 (d, J=1.5 Hz, 1H), 8.83 (dd, J=8.0, 1.5 Hz, 1H), 8.73 (d, J=5.0 Hz, 1H), 8.15-8.10 (m, 2H), 7.66 (s, 1H), 7.34 (s, 1H), 7.18 (d, J=5.0 Hz, 1H), 4.25 (s, 2H), 2.46 (s, 3H).

Provenance & Evidence