1,2-Dichloroethane → HCID 118093098, compound

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Reaction Steps

A mixture of 2-(5-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)pyridin-2-yl)acetic acid (8.4 mg, 0.020 mmol), dimethylamine (0.05 ml, 0.100 mmol, 2M), EDC (8.6 mg, 0.045 mmol), HOBT (7.8 mg, 0.051 mmol), DIEA (10 μl, 0.057 mmol) in 1,4-dioxane (0.8 ml) was stirred at room temperature for 16 hours. The mixture was purified by reversed phase HPLC to afford N,N-dimethyl-2-(5-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)pyridin-2-yl)acetamide (8.4 mg, 0.016 mmol). MS ESI calc'd. for C21H21F3N5O [M+H]+ 416. found 416. 1H NMR (600 MHz, CD3OD): δ 8.97 (s, 1H), 8.71 (d, J=4.8 Hz, 1H), 8.62 (d, J=6.0 Hz, 1H), 8.09 (s, 1H), 7.89 (d, J=6.0 Hz, 1H), 7.60 (s, 1H), 7.26 (s, 1H), 7.13 (d, J=4.8 Hz, 1H), 4.25 (s, 2H), 3.18 (s, 3H), 3.00 (s, 3H), 2.43 (s, 3H).

Provenance & Evidence