Sodium Hydroxide → HCID 118092592, compound

Participants

Reaction Steps

Ethanol (1.00 mL) and aqueous sodium hydroxide (1 M, 0.075 mL, 0.075 mmol) were added to methyl {[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)pyridin-2-yl]sulfamoyl}acetate (TFA salt, 20.0 mg, 0.034 mmol) and stirred at room temperature for 45 minutes. The reaction mixture was concentrated under reduced pressure. The residue was purified by reverse phase chromatography (10-80% acetonitrile in water+0.1% TFA) to give {[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)pyridin-2-yl]sulfamoyl}acetic acid (TFA salt) as a colorless solid. MS APCI calc'd for C19H17F3N5O4S [M+H]+ 468. found 468. 1H NMR (500 MHz, DMSO-d6) δ 10.25 (s, 1H), 8.83 (d, J=5.2 Hz, 1H), 8.54-8.21 (m, 1H), 8.00 (s, 1H), 7.88 (s, 1H), 7.53 (s, 1H), 7.27 (d, J=5.1 Hz, 1H), 7.14 (s, 2H), 4.38-3.68 (m, 2H), 2.34 (s, 3H).

Provenance & Evidence