Methanol → HCID 118092590, compound

Participants

Reaction Steps

A solution of KOH in MeOH (1 M, 2 mL, 2.00 mmol) was added to the 3-hydroxy-3-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)pyridin-3-yl]cyclopentanecarboxylate (60 mg, 0.123 mmol). The reaction mixture was stirred at room temperature, overnight, diluted with 2N HCl and extracted with DCM (3×). The combined organic layers were dried under reduced pressure to give 3-hydroxy-3-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)pyridin-3-yl]cyclopentanecarboxylic acid. MS ESI calc'd for C23H22F3N4O3 [M+H]+ 459. found 459. 1H NMR (500 MHz, MeOD) δ 9.01 (s, 1H), 8.92 (d, J=6.0 Hz, 1H), 8.74 (d, J=5.0 Hz, 1H), 8.19 (s, 1H), 7.63 (s, 2H), 7.35 (s, 1H), 7.17 (d, J=5.0 Hz, 1H), 2.51-2.00 (m, 7H), 1.19 (s, 3H).

Provenance & Evidence