反应详情

Sodium borohydride (2.8 g, 0.074 mol) was added portionwise to a solution of 4-methyl-1-[4-(trifluoromethyl)phenyl]pentan-1-one [Intermediate 1; Step 1] in EtOH (50 mL) cooled in ice. When addition was complete (30 min) the mixture was stirred at RT for 1 h then quenched with NH4Cl solution (50 mL) followed by 2N HCl (20 mL). Extraction with ether (3×50 mL) followed by drying (MgSO4) and concentration of the organic phase gave 4-methyl-1-(4-(trifluoromethyl)phenyl)pentan-1-ol as a colourless oil.

1. temperaturecooled in ice
2. additionWhen addition
3. custom(30 min)
4. customthen quenched with NH4Cl solution (50 mL)
5. extractionExtraction with ether (3×50 mL)
6. dry with materialby drying (MgSO4) and concentration of the organic phase