Hydrochloric Acid → HCID 53487253, compound

Participants

Reaction Steps

2-methyl-N-{(1S)-3-phenyl-1-[4-(trifluoromethyl)phenyl]propyl}propane-2-sulfinamide (JACS, 2005, 127, 1092-3) (8.3 g, 21.7 mmol) was dissolved in methanol (50 mL) and a 4M solution of HCl in dioxane (10.8 mL) was added. The solution was stirred at RT for 1 h then concentrated. The residue was triturated with isohexane to give a colourless solid which was collected by filtration. 1H NMR (400 MHz), δ (ppm) (DMSO-D6): 8.7 (3H, s), 7.85 (2H, d, J 8.3 Hz), 7.77 ((2H, d, J 8.3 Hz), 7.29-7.26 (2H, m), 7.20-7.13 (3H, m), 4.36 (1H, m), 2.4-2.35 (2H, m), 2.35-2.25 (m, 1H), 2.2-2.1 (1H, m).

Provenance & Evidence