Hydrochloric Acid → HCID 118093137, compound

Participants

Reaction Steps

HCl (4 M in dioxanes, 0.844 mL, 3.38 mmol) followed by palladium on carbon (599 mg, 0.281 mmol) were added to a mixture of 5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)pyridine-2-carbonitrile (1.00 g, 2.81 mmol) and ethanol (200 mL). The reaction mixture was purged and flushed with H2(g) and was stirred under 1 atm of H2(g) for 3.5 hours at room temperature. The reaction mixture was filtered through CELITE, washed with ethanol and ethyl acetate and concentrated under reduced pressure to afford N-{3-[6-(Aminomethyl)pyridin-3-yl]-5-methylphenyl}-4-(trifluoromethyl)pyrimidin-2-amine hydrochloride as a yellow powder. MS APCI calc'd for C18H17F3N5 [M+H]+ 360. found 360.

Provenance & Evidence