Potassium Carbonate → Trifluoroacetic acid

Participants

Reaction Conditions

Reaction Steps

Hydroxylamine hydrochloride (101 mg, 1.46 mmol) and potassium carbonate (201 mg, 1.46 mmol) were added to a mixture of 2-methyl-2-{[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)pyridin-2-yl]amino}propanenitrile (100 mg, 0.242 mmol) in ethanol (404 μL). The reaction stirred at 85° C. overnight. The reaction mixture was diluted with DMSO, filtered, and purified by reverse phase HPLC (5-95% acetonitrile in water+0.5% TFA) to yield (1Z)—N′-hydroxy-2-methyl-2-{[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)pyridin-2-yl]amino}propanimidamide as a bis-TFA salt. MS APCI calc'd for C21H23F3N7O [M+H]+ 446. found 446.

Provenance & Evidence