Di-tert-butyl peroxide → HCID 131735919, compound

Participants

Reaction Steps

A mixture of ethyl 2,2-difluoro-3-{[(methylsulfanyl)carbonothioyl]oxy}-3-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)pyridin-2-yl]propanoate (68.5 mg, 0.120 mmol), anhydrous dioxane (5.00 mL), diphenylphosphine oxide (25.6 mg, 0.127 mmol) and di-tert-butyl peroxide (10.0 μL, 0.054 mmol) was heated to reflux for 6 hours under Ar(g). The reaction mixture was concentrate under reduced pressure and the residue was purified by reverse phase HPLC to afford ethyl 2,2-difluoro-3-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)pyridin-2-yl]propanoate. MS APCI C22H20F5N4O2 [M+H]+ 467. found 467.

Provenance & Evidence