Potassium Carbonate → Trifluoroacetic acid

Participants

Reaction Steps

Dimethyl (1-diazo-2-oxopropyl)phosphonate (0.200 mL, 1.15 mmol) was added to a solution of 5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)pyridine-2-carbaldehyde (201 mg, 0.560 mmol) and potassium carbonate (155 mg, 1.12 mmol) in dry methanol (8.00 mL). The mixture was stirred at room temperature for 2 hours. The mixture was diluted with water and extracted with ethyl acetate. The organic layer was concentrated under reduced pressure and the residue was directly purified by reverse phase HPLC to yield N-[3-(6-ethynylpyridin-3-yl)-5-methylphenyl]-4-(trifluoromethyl)pyrimidin-2-amine as a TFA salt. MS APCI C19H14F3N4 [M+H]+ 355. found 355.

Provenance & Evidence