Ammonium Chloride → HCID 178488700, compound

Participants

Reaction Steps

7-(cyanomethyloxy)-3′,4′,5-trimethoxy flavone (0.3 g, 0.82 mmol) obtained in Step 2, ammonium chloride (0.13 g, 2.45 mmol) and sodium azide (0.08 g, 1.23 mmol) were dissolved in N,N′-dimethylformamide (6 mL). After the reaction was carried out at 120° C. for 3 hours, the reaction solution was cooled to room temperature. The resulting solids were filtered and washed with ethyl acetate and n-hexane. The washed solids were dissolved in a 3:1 mixed solvent of chloroform and methanol and dried over anhydrous sodium sulfate to remove the solvent. The resulting residue was recrystallized from a 1:1 mixed solvent of ethyl acetate and chloroform to give 0.195 g (yield: 58%) of the title compound.

Provenance & Evidence