反应详情

Epoxy alcohol 10, 1.2 eq of TESOTf, and 1.5 eq of collidine were reacted as in the preparation of 16 give 80% of aldehyde 11. 1H NMR (CDCl3, 500.35 MHz) δ:9.64 (1H, d J=0.77 Hz), 7.30-7.05 (5H,m) 4.37 (1H, J=3.06, 10.40 Hz), 2.76 (1H, d J=6.64 Hz), 2.75 (2H, d J=7.42 Hz), 2.27 (1H, qdd, J=7.00, 3.38, 0.77 Hz), 1.10 (3H, d, J=7.04 Hz), 0.95-0.75 (6H, m), 0.6-0.4 (9H, m). 1H NMR integration of δ 9.64 to the contaminant δ 9.71 indicated a 93.6:6.4 ratio.