Triethylamine → HCID 89649808, compound

Participants

Reaction Steps

A solution of 4-chlorobutanoyl chloride (4.12 mL, 36.84 mmol) in DCM (50 mL) was added over 15 mins to an ice-cooled solution of 3-bromo-4-fluoro-aniline (7 g, 36.84 mmol) and triethylamine (5.12 mL, 36.84 mmol) in DCM (100 mL) under N2. After addition was complete the cooling bath was removed and the solution stirred at ambient temp for 4 h. The reaction solution was washed with water (2×150 ml) dried (MgSO4) and concentrated to a white solid, which was dried at RT under vacuum overnight to give N-(3-bromo-4-fluoro-phenyl)-4-chloro-butanamide (D57) (9.04 g);

Provenance & Evidence