反应详情

温度

0 °C

Tin (II) chloride (86.65 g, 457.0 mmol) was added to a solution of 1-methyl-5-(4-methyl-2-nitro-phenylamino)-1H-pyrazole-4-carboxylic acid ethyl ester from Example E2.1 (28.00 g, 91.4 mmol) in methanol and the mixture heated at reflux for 3 days. The solvent was removed in vacuo and the residue taken up in EtOAc (400 ml) and cooled to 0° C. 35% Ammonia solution was added to pH 14, and the mixture was stirred for 15 min before being filtered through Celite® filter agent. The filtrate was washed with 2M NH3 and brine and concentrated in vacuo. The residue was purified by flash chromatography on silica gel (eluant; 6% methanol:94% dichloromethane rising to 10% methanol:90% dichloromethane) to yield the title compound (12.8 g, 52%).

1. temperaturethe mixture heated
2. temperatureat reflux for 3 days
3. customThe solvent was removed in vacuo
4. addition35% Ammonia solution was added to pH 14
5. filtrationbefore being filtered through Celite®
6. filtrationfilter agent
7. washThe filtrate was washed with 2M NH3 and brine
8. concentrationconcentrated in vacuo
9. customThe residue was purified by flash chromatography on silica gel (eluant; 6% methanol:94% dichloromethane rising to 10% methanol:90% dichloromethane)