HCID 89649473, compound → HCID 89649261, compound

Participants

Reaction Steps

A solution of 4-(3-benzyloxy-4-fluoro-phenyl)-1-methyl-pyrazole (which may be prepared as described in Description 78) (760 mg, 2.69 mmol) in methanol (15 mL) was hydrogenated through a H-Cube using a 10% Pd/C (70 mm cartridge) at 50° C. with a Flow rate of 1 mL/min. The eluent was concentrated in vacuo and gave 2-fluoro-5-(1-methylpyrazol-4-yl)phenol (419.2 mg, 2.0721 mmol, 77% yield) (D79) as a colourless solid;

Provenance & Evidence