反应详情

4-(tert-Butoxycarbonylamino-methyl)-3-methyl-benzoic acid methyl ester from Example E2h.3 (1.04 g, 3.7 mmol) was dissolved in dioxan (20 ml). 1N NaOH solution (5.6 ml, 5.6 mmol) was added and the mixture was stirred for 18 h at room temperature then concentrated in vacuo. The residue was redissolved in EtOAc, washed with 1N KHSO4 then brine, dried and concentrated in vacuo to yield the title compound (800 mg, 81%).

1. concentrationthen concentrated in vacuo
2. dissolutionThe residue was redissolved in EtOAc
3. washwashed with 1N KHSO4
4. dry with materialbrine, dried
5. concentrationconcentrated in vacuo