Hydrochloric Acid → HCID 89649235, compound

Participants

Reaction Steps

4 M HCl in dioxane (3 mL, 12 mmol) was added to the tert-butyl (2R,5S)-6-oxo-2-[4-[4-(trifluoromethyl)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]nonane-1-carboxylate and the reaction mixture stirred for 16 hours. The mixture was concentrated at reduced pressure and then re-dissolved in methanol. The solution was applied to an SCX column which was eluted with methanol, followed by 0.5 M ammonia in methanol. Basic product containing fractions were combined and concentrated to give (2R,5S)-2-[4-[4-(trifluoromethyl)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]nonan-6-one as a colourless solid (36 mg);

Provenance & Evidence