1,4-Dioxane → HCID 89649349, compound

Participants

Reaction Steps

A solution of tert-butyl (2R,5R)-2-[4-(5-ethoxy-2-fluoro-phenyl)-3-methyl-2-pyridyl]-7-methyl-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylate (which may be prepared as described in Description 100)(74.2 mg, 0.1500 mmol) in 4M HCl in dioxane (0.38 mL, 1.53 mmol) was stirred for 2 hours. The reaction was then concentrated in vacuo. The residue was loaded onto an SCX cartridge which was eluted with MeOH and 0.5 M methanolic ammonia. The basic fractions were combined and concentrated in vacuo to give (2R,5R)-2-[4-(5-ethoxy-2-fluoro-phenyl)-3-methyl-2-pyridyl]-7-methyl-1,7-diazaspiro[4.4]nonan-6-one (55.6 mg, 0.1450 mmol, 94.524% yield) as a colourless oil (5182RTS331-A1, >95% pure);

Provenance & Evidence