HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → 4-Azidomethyl-3-fluorobenzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | Methyl 4-(bromomethyl)-3-fluorobenzoate | HCID 18766370 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Azidomethyl-3-fluorobenzoic acid methyl ester | HCID 57426182 | 100% |
Reaction Steps
Sodium azide (609 mg) was added to a solution of 4-bromomethyl-3-fluorobenzoic acid methyl ester from Example E3.2 (2.1 g, 8.5 mmol) in DMF (30 ml). The mixture was stirred for 18 h, diluted with EtOAc, washed with water and brine and concentrated in vacuo to give a colourless oil identified as the title compound (1.8 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202858B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-e9a6428177bc43d1a2905c16a88ea4c3 |
| Source note | uspto-grants-2012_06 |