HCID 57426182, compound → Methyl 4-(aminomethyl)-3-fluorobenzoate

HRID 220771Notes

Reaction equation

HRID 220771 reaction equation
[H][H].[CH3:3][O:4][C:5](=[O:17])[C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]=[N+]=[N-])=[C:8]([F:16])[CH:7]=1>CO>[CH3:3][O:4][C:5](=[O:17])[C:6]1[CH:11]=[CH:10][C:9]([CH2:12][NH2:13])=[C:8]([F:16])[CH:7]=1

Participants

4

Reactant 2

HCID 57426182HCID 57426182, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21257182Methyl 4-(aminomethyl)-3-fluorobenzoateYield 83%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrogen was passed through a degassed solution of 4-azidomethyl-3-fluorobenzoic acid methyl ester from Example E3.3 (2.11 g, 10 mmol) in methanol containing 10% palladium on carbon for 2 h. The reaction mixture was filtered through Celite® filter agent and the filtrate was concentrated in vacuo to give a colourless oil identified as the title compound (1.51 g, 83%).

Workup

  1. filtrationThe reaction mixture was filtered through Celite®
  2. filtrationfilter agent
  3. concentrationthe filtrate was concentrated in vacuo
  4. customto give a colourless oil

Sources & evidence

ORD record
ord-f00fecd360784249b375eaf6613fbb7c
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

Loading…