HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-((((Tert-butoxy)carbonyl)amino)methyl)-3-fluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(tert-Butoxycarbonylamino-methyl)-3-fluorobenzoic Acid Methyl Ester | HCID 59767701 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-((((Tert-butoxy)carbonyl)amino)methyl)-3-fluorobenzoic acid | HCID 23023165 | 100.4% |
Reaction Steps
To a solution of 4-(tert-butoxycarbonylamino-methyl)-3-fluorobenzoic acid methyl ester from Example E3.5 (640 mg, 2.25 mmol) in dioxan (40 ml) was added 1N NaOH (4.5 ml, 4.5 mmol). The mixture was stirred for 18 h, diluted with EtOAc, washed with 1N KHSO4, water and brine and concentrated in vacuo to give a white solid identified as the title compound (608 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202858B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-55e658be137d45bfb84319c930d0d0ac |
| Source note | uspto-grants-2012_06 |