反应详情

6-Benzoyl-2-methyl-1,4,5,6-tetrahydro-1,3,6-triaza-benzo[e]azulene from Example E5.8 (160 mg, 0.53 mmol) was dissolved in a 6M HCl/dioxan solution (50 ml) and heated at reflux for 18 h. The reaction mixture was cooled to room temperature and reduced in vacuo. The residue was partitioned between EtOAc and saturated NaHCO3 (aq) and the layers were separated. The organic layer was washed with brine, dried, filtered and reduced in vacuo to yield the title compound (69 mg, 66%).

1. temperatureheated
2. temperatureat reflux for 18 h
3. customThe residue was partitioned between EtOAc and saturated NaHCO3 (aq)
4. customthe layers were separated
5. washThe organic layer was washed with brine
6. customdried
7. filtrationfiltered