HRID2207842

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CC=C(c2cnc(Cl)nc2OC2CN(c3ccc4ccccc4n3)C2)CC1

HCID58547741

Tert-butyl 4-(2-chloro-4-((1-(quinolin-2-YL)azetidin-3-YL)oxy)pyrimidin-5-YL)-5,6-dihydropyridine-1(2H)-carboxylate

C26H28ClN5O3

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC(c2cncnc2OC2CN(c3ccc4ccccc4n3)C2)CC1

HCID58547690

未命名化合物

收率 78%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of tert-butyl 4-(2-chloro-4-((1-(quinolin-2-yl)azetidin-3-yl)oxy)pyrimidin-5-yl)-5,6-dihydropyridine-1(2H)-carboxylate (472 mg, 0.95 mmol) in MeOH (10 mL) was added Pd/C (10%, 200 mg). The reaction solution was stirred at room temperature overnight under H2 atmosphere. The mixture was filtered through CELITE® and concentrated to give the product (307 mg, 0.66 mmol, yield: 78%). ESI-MS (M+1): 462 calc. for C26H31N5O3 461.

WORKUP

后处理

filtrationThe mixture was filtered through CELITE®
concentrationconcentrated