HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-benzoyl-2-methyl-5,6-dihydro-4H-1-oxa-3,6-diaza-benzo[e]azulene → 2-methyl-5,6-dihydro-4H-benzo[b]oxazolo[5,4-d]azepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-benzoyl-2-methyl-5,6-dihydro-4H-1-oxa-3,6-diaza-benzo[e]azulene | HCID 23112369 | — |
| Solvent | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Product | 2-methyl-5,6-dihydro-4H-benzo[b]oxazolo[5,4-d]azepine | HCID 23112365 | 83% |
Reaction Steps
6-Benzoyl-2-methyl-5,6-dihydro-4H-1-oxa-3,6-diaza-benzo[e]azulene from Example E5.8 (11.0 g, 3.25 mmol) was reacted with a 6M HCl/dioxan solution (100 ml) using an analogous procedure to that described for Example E5.9 to yield the title compound (540 mg, 82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202858B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-d969e83acca0427ca619de02d5dee0ad |
| Source note | uspto-grants-2012_06 |