Thionyl Chloride → 3-(3-Bromo-4-fluoro-phenyl)-acryloyl chloride

https://huagongshe.com/reaction/2207879

Participants

Role	Name	HCID	Charge
Reactant	Thionyl Chloride	HCID 24386	—
Reactant	3-(3-Bromo-4-fluorophenyl)-2-propenoic acid	HCID 688311	—
Product	3-(3-Bromo-4-fluoro-phenyl)-acryloyl chloride	HCID 2756996	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

3-(3-Bromo-4-fluoro-phenyl)-acrylic acid (3.3 g, 13.3 mmol) prepared in Step 1 was added to thionyl chloride (10.0 mL). The reaction mixture was stirred at 100° C. for 2 hours, concentrated under reduced pressure. The resulting residue was concentrated under reduced pressure three times, along with using toluene, to give 3.5 g of the titled compound as an unpurified dark brown liquid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09376420B2
Source dataset	uspto-grants-2016_06
ORD ID	ord-1bc6024e22d84855b8396c2585ada29d
Source note	uspto-grants-2016_06