Malonic Acid → HCID 53401839, compound

Participants

Reaction Conditions

Reaction Steps

6-Bromo-pyridin-2-carbaldehyde (5.0 g, 26.9 mmol), malonic acid (6.3 g, 60.5 mmol), and piperidine (2.2 mL, 22.4 mmol) were added to pyridine (16.3 mL). The reaction mixture was stirred at 100° C. for 1 hour, concentrated under reduced pressure, and then distilled water was added thereto. The mixture was filtered and then the resulting solid was dried under reduced pressure to give 4.5 g of the titled compound as a brown solid.

Provenance & Evidence