HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2207893Generated: November 2, 2026
Thionyl Chloride → 3-(5-Bromo-pyridin-3-yl)-acryloyl chloride
https://huagongshe.com/reaction/2207893
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(5-Bromopyridin-3-yl)prop-2-enoic acid | HCID 2784735 | — |
| Product | 3-(5-Bromo-pyridin-3-yl)-acryloyl chloride | HCID 131735945 | — |
Reaction Steps
3-(5-Bromo-pyridin-3-yl)-acrylic acid (26.2 g, 114.7 mmol) prepared in Step 1 was added to thionyl chloride (100.0 mL). The reaction mixture was stirred at 100° C. for 2 hours and then concentrated under reduced pressure. The resulting residue was concentrated under reduced pressure three times, along with using toluene, to give 3-(5-bromo-pyridin-3-yl)-acryloyl chloride as an unpurified dark brown liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09376420B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-01fe754c286948e4b62d352405604faf |
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| Source note | uspto-grants-2016_06 |
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