HCID 118432106, compound → HCID 118431821, compound

Participants

Reaction Steps

To a solution of 1-[5-(5-bromo-thiophen-2-yl)-1-(2,4-difluoro-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-2,2,2-trifluoro-ethanol (9.9 g, 22.4 mmol) prepared in Step 6 in dichloromethane (100.0 mL), was slowly added DMP (10.5 g, 24.7 mmol) at 0° C. The reaction mixture was stirred at room temperature for 1 hour, quenched with a saturated sodium thiosulfate solution, and then extracted with diethyl ether. The extract was washed with a saturated solution of sodium hydrogen carbonate, dried on anhydrous magnesium sulfate, and then concentrated under reduced pressure to give a yellow liquid residue. The resulting residue was purified by silica gel column chromatography (eluent: dichloromethane/n-hexane=2/5) to give 8.5 g of the titled compound as a yellow solid.

Provenance & Evidence