反应详情

Acetyl chloride (2.0 mL, 28.7 mmol) was slowly added to methanol (10.0 mL) at 0° C. under stirring. A solution of 4-(3′-ethoxy-biphenyl-4-yl)-2-oxo-3-butenoic acid (2.5 g, 8.4 mmol) prepared in Step 2 in methanol (10.0 mL) was added to the reaction mixture at room temperature. The reaction mixture was stirred at room temperature for 1 hour, additionally at 80° C. for 16 hours, and then filtered at room temperature to give 1.0 g of the titled compound as a yellow solid.

1. stirringThe reaction mixture was stirred at room temperature for 1 hour, additionally at 80° C. for 16 hours
2. filtrationfiltered at room temperature