Acetyl chloride → HCID 131735959, compound

Participants

Reaction Steps

Acetyl chloride (4.8 mL, 68.5 mmol) was slowly added at 0° C. to methanol (28.0 mL) under stirring. A solution of 4-(4-bromo-2-fluoro-phenyl)-2-oxo-3-butenoic acid (5.5 g, 20.1 mmol) prepared in Step 1 in methanol (5.0 mL) was added to the reaction mixture at room temperature. The reaction mixture was stirred at room temperature for 1 hour, additionally at 80° C. for 16 hours, and then filtered at room temperature to give 4.7 g of the titled compound as a yellow solid.

Provenance & Evidence