2-Chlorophenylhydrazine hydrochloride → HCID 118431880, compound

Participants

Reaction Conditions

Reaction Steps

4-(4-Bromo-2-fluoro-phenyl)-2-oxo-3-butenoic acid methyl ester (2.0 g, 7.0 mmol) prepared in Step 2 and 2-chlorophenylhydrazine hydrochloride (1.4 g, 7.7 mmol) were added to acetic acid (25.0 mL). The reaction mixture was stirred at 80° C. for 2 hours, concentrated under reduced pressure, and then ethyl acetate was added thereto. The mixture was washed with a saturated solution of sodium hydrogen carbonate, dried on anhydrous magnesium sulfate, and then concentrated under reduced pressure to give 3.0 g of the titled compound as a black liquid.

Provenance & Evidence