Thionyl Chloride → HCID 118432179, compound

Participants

Reaction Conditions

Reaction Steps

5-(6-Bromo-pyridin-3-yl)-1-(2-chloro-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid (450.0 mg, 1.2 mmol) prepared in Step 3 was added to thionyl chloride (5.0 mL). The reaction mixture was stirred at 100° C. for 2 hours and then concentrated under reduced pressure. The resulting residue was concentrated under reduced pressure three times, along with using toluene, to give 5-(6-bromo-pyridin-3-yl)-1-(2-chloro-phenyl)-4,5-dihydro-1H-pyrazole-3-carbonyl chloride as a dark brown liquid.

Provenance & Evidence