Acetyl chloride → HCID 131735962, compound

Participants

Reaction Steps

Acetyl chloride (2.9 mL, 41.0 mmol) was slowly added at 0° C. to methanol (15.0 mL) under stirring. A solution of 4-(4-bromo-3-fluoro-phenyl)-2-oxo-3-butenoic acid (3.2 g, 11.7 mmol) prepared in Step 1 in methanol (5.0 mL) was added to the reaction mixture at room temperature. The reaction mixture was stirred at room temperature for 1 hour, additionally at 80° C. for 16 hours, and then filtered at room temperature to give 1.1 g of the titled compound as a pale yellow solid.

Provenance & Evidence