Methanol → HCID 118432180, compound

Participants

Reaction Conditions

Reaction Steps

The 5-(4-bromo-phenyl)-1-(2,4-difluoro-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid methyl ester in the form of a yellow liquid (73.4 g, 185.8 mmol) and a solution of potassium hydroxide (20.9 g, 371.6 mmol) in distilled water (400.0 mL) were added to methanol (400.0 mL). The reaction mixture was stirred at 70° C. for 4 hours and then concentrated under reduced pressure to discard methanol. The resulting residue was washed with diethyl ether, acidified by a 1N hydrochloric acid solution, and then extracted with ethyl acetate. The extract was washed with distilled water and brine, dried on anhydrous magnesium sulfate, and then concentrated under reduced pressure to give 70.0 g of the titled compound as a yellow solid.

Provenance & Evidence