Acetyl chloride → HCID 131735953, compound

Participants

Reaction Steps

Acetyl chloride (23.0 mL, 325.6 mmol) was slowly added at 0° C. to methanol (100.0 mL) under stirring. A solution of 4-(5-bromo-thiophen-2-yl)-2-oxo-3-butenoic acid (25.0 g, 95.8 mmol) prepared in Step 1 in methanol (25.0 mL) was added at 0° C. to the reaction mixture. The reaction mixture was stirred at room temperature for 1 hour, additionally at 80° C. for 3 hours, and then filtered at room temperature to give 23.6 g of the titled compound as a yellow solid.

Provenance & Evidence