Thionyl Chloride → HCID 118432046, compound

Participants

Reaction Steps

5-(5-Bromo-thiophen-2-yl)-1-(2-chloro-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid (18.1 g, 46.9 mmol) prepared in Step 4 was added to thionyl chloride (200.0 mL). The reaction mixture was stitted at 100° C. for 2 hours and then concentrated under reduced pressure. The resulting residue was concentrated under reduced pressure three times, along with using toluene, to give 5-(5-bromo-thiophen-2-yl)-1-(2-chloro-phenyl)-4,5-dihydro-1H-pyrazole-3-carbonyl chloride as a dark brown liquid.

Provenance & Evidence