Thionyl Chloride → HCID 118431664, compound

Participants

Reaction Conditions

Reaction Steps

1-(4-Bromo-phenyl)-5-(2-chloro-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid (5.4 g, 14.3 mmol) prepared in Step 4 was added to thionyl chloride (50.0 mL). The reaction mixture was stirred at 100° C. for 2 hours and then concentrated under reduced pressure. The resulting residue was concentrated under reduced pressure three times, along with using toluene, to give 1-(4-bromo-phenyl)-5-(2-chloro-phenyl)-4,5-dihydro-1H-pyrazole-3-carbonyl chloride as a dark brown liquid.

Provenance & Evidence