3-Bromophenylhydrazine hydrochloride → HCID 118431728, compound

Participants

Reaction Conditions

Reaction Steps

4-(2-Chloro-phenyl)-2-oxo-3-butenoic acid methyl ester (1.4 g, 6.0 mmol) prepared in Step 2 of Preparation 24 and 3-bromophenylhydrazine hydrochloride (1.4 g, 6.1 mmol) were added to acetic acid (20.0 mL). The reaction mixture was stirred at 125° C. for 3 hours, concentrated under reduced pressure, and then ethyl acetate was added thereto. The reaction mixture was washed with a saturated solution of sodium hydrogen carbonate, dried on anhydrous magnesium sulfate, and then concentrated under reduced pressure to give a yellow liquid residue. The resulting yellow liquid residue was crystallized from methanol to give 1.2 g of the titled compound as a pale yellow solid.

Provenance & Evidence