Dichloromethane → HCID 118432003, compound

Participants

Reaction Steps

1-(2,4-difluoro-phenyl)-5-[3-(1,2,3,6-tetrahydropyridin-4-yl)-phenyl]-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole trifluoroacetate (30.0 mg, 0.05 mmol) prepared in Example 61, triethylamine (20.3 uL, 0.15 mmol) and methanesulfonyl chloride (1.9 uL, 0.06 mmol) were added at 0° C. to dichloromethane (1.0 mL). The reaction mixture was stirred at room temperature for 2 hours. Distilled water was added to the reaction mixture, which was then extracted with dichloromethane two times. The combined extract was washed with a 1N hydrochloric acid solution, a saturated sodium carbonate solution, and brine, dried on anhydrous magnesium sulfate, and then concentrated under reduced pressure to give a yellow liquid residue. The resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/3) to give 1.9 mg of the titled compound as a yellow liquid.

Provenance & Evidence