Dichloromethane → HCID 118432089, compound

Participants

Reaction Steps

1-(2-Chloro-phenyl)-5-[2-(1,2,3,6-tetrahydropyridin-4-yl)-pyridin-6-yl]-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole trifluoroacetate (20.0 mg, 0.04 mmol) prepared in Step 1, triethylamine (15.0 uL, 0.11 mmol) and methanesulfonyl chloride (4.1 uL, 0.05 mmol) were added at 0° C. to dichloromethane (0.5 mL). The reaction mixture was stirred at room temperature for 2 hours. Distilled water was added to the reaction mixture, which was then extracted with dichloromethane two times. The combined extract was washed with 1N hydrochloride, a saturated solution of sodium carbonate, and brine, dried on anhydrous magnesium sulfate, and then concentrated under reduced pressure to give a yellow liquid residue. The resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/2) to give 3.0 mg of the titled compound as a yellow liquid.

Provenance & Evidence