Dimethylsulphamoyl chloride → HCID 118432165, compound

HRID 2208008Notes

Reaction equation

FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[CH:19]([C:20]2[N:25]=[C:24]([C:26]3[CH2:27][CH2:28][NH:29][CH2:30][CH:31]=3)[CH:23]=[CH:22][CH:21]=2)[CH2:18][C:17]([C:32]([F:38])([F:37])[C:33]([F:36])([F:35])[F:34])=[N:16]1.[CH3:39][N:40]([CH3:45])[S:41](Cl)(=[O:43])=[O:42]>>[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[CH:19]([C:20]2[N:25]=[C:24]([C:26]3[CH2:27][CH2:28][N:29]([S:41](=[O:43])(=[O:42])[N:40]([CH3:45])[CH3:39])[CH2:30][CH:31]=3)[CH:23]=[CH:22][CH:21]=2)[CH2:18][C:17]([C:32]([F:38])([F:37])[C:33]([F:34])([F:36])[F:35])=[N:16]1

Participants

Reactant 2

HCID 83372Dimethylsulphamoyl chloride

HCID 118431831HCID 118431831, compound

Product 1

HCID 118432165HCID 118432165, compound

Procedure

The titled compound was prepared in accordance with the same procedures as in Step 2 of Example 158, except for using 1-(2-chloro-phenyl)-5-[2-(1,2,3,6-tetrahydropyridin-4-yl)-pyridin-6-yl]-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole trifluoroacetate prepared in Step 1 of Example 158; and using dimethylsulfamoyl chloride instead of methanesulfonyl chloride.

Sources & evidence

ORD record: ord-0af3ccdf017a4c5e8a2684d202009a18
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376420B2

Reaction notes

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