1,4-Dioxane hydrochloride → HCID 136346634, compound

HRID 220803Notes

Reaction equation

HRID 220803 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15](=[O:42])[NH:16][CH2:17][CH:18]2[CH2:23][CH2:22][CH:21]([C:24]([N:26]3[CH2:35][C:34]4[CH:33]=[N:32][N:31]([CH3:36])[C:30]=4[NH:29][C:28]4[CH:37]=[C:38]([CH3:41])[CH:39]=[CH:40][C:27]3=4)=[O:25])[CH2:20][CH2:19]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:43].O1CCOCC1>>[ClH:43].[CH3:36][N:31]1[C:30]2[NH:29][C:28]3[CH:37]=[C:38]([CH3:41])[CH:39]=[CH:40][C:27]=3[N:26]([C:24]([CH:21]3[CH2:20][CH2:19][CH:18]([CH2:17][NH:16][C:15](=[O:42])[CH2:14][CH:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)[CH2:23][CH2:22]3)=[O:25])[CH2:35][C:34]=2[CH:33]=[N:32]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 136128412HCID 136128412, compound

Product 1

HCID 136346634HCID 136346634, compoundYield 93%

Procedure

A solution of 4-({[4-(3,6-dimethyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-cyclohexylmethyl]-carbamoyl}-methyl)-piperidine-1-carboxylic acid tert-butyl ester (Compound Number 228)(259 mg, 0.45 mmol) was reacted with 4N HCl/dioxan using an analogous procedure to that described for Example E4.2 to yield the title compound (230 mg, 93%).

Sources & evidence

ORD record
ord-47db678338a8405486b71520a1e32f56
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

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