Dimethylsulphamoyl chloride → HCID 118431810, compound

HRID 2208031Notes

Reaction equation

FC(F)(F)C(O)=O.[F:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH:20]([C:21]2[S:22][C:23]([C:26]3[CH2:27][CH2:28][NH:29][CH2:30][CH:31]=3)=[CH:24][CH:25]=2)[CH2:19][C:18]([C:32]([F:38])([F:37])[C:33]([F:36])([F:35])[F:34])=[N:17]1.[CH3:39][N:40]([CH3:45])[S:41](Cl)(=[O:43])=[O:42]>>[F:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH:20]([C:21]2[S:22][C:23]([C:26]3[CH2:27][CH2:28][N:29]([S:41](=[O:43])(=[O:42])[N:40]([CH3:45])[CH3:39])[CH2:30][CH:31]=3)=[CH:24][CH:25]=2)[CH2:19][C:18]([C:32]([F:37])([F:38])[C:33]([F:35])([F:36])[F:34])=[N:17]1

Participants

Reactant 2

HCID 83372Dimethylsulphamoyl chloride

HCID 118431668HCID 118431668, compound

Product 1

HCID 118431810HCID 118431810, compound

Procedure

The titled compound was prepared in accordance with the same procedures as in Step 2 of Example 200, except for using 1-(2,4-difluoro-phenyl)-5-[5-(1,2,3,6-tetrahydropyridin-4-yl)-thiophen-2-yl]-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole trifluoroacetate Prepared in Step 1 of Example 200; and using dimethylsulfamoyl chloride instead of methanesulfonyl chloride.

Sources & evidence

ORD record: ord-0ae2ddfebf564c5b87447e11b17e2c68
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376420B2

Reaction notes

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