Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate → HCID 118431799, compound
Reaction equation
Br[C:2]1[CH:3]=[C:4]([N:8]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=3[F:20])[CH2:11][C:10]([C:21]([F:27])([F:26])[C:22]([F:25])([F:24])[F:23])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[C:28]([N:35]1[CH2:40][CH:39]=[C:38](B2OC(C)(C)C(C)(C)O2)[CH2:37][CH2:36]1)([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29]>>[C:28]([N:35]1[CH2:36][CH:37]=[C:38]([C:2]2[CH:3]=[C:4]([N:8]3[CH:12]([C:13]4[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=4[F:20])[CH2:11][C:10]([C:21]([F:26])([F:27])[C:22]([F:25])([F:23])[F:24])=[N:9]3)[CH:5]=[CH:6][CH:7]=2)[CH2:39][CH2:40]1)([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29]Participants
3
Procedure
The titled compound was prepared in accordance with the same procedures as in Example 204, except for using 1-(3-bromo-phenyl)-5-(2,4-difluoro-phenyl)-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole prepared in Step 4 of Preparation 14; and using 1-BOC-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine instead of 3-(methylthio)phenylboronic acid.
Sources & evidence
- ORD record
- ord-0a055f75cddd49b0985959888c42fdb6
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09376420B2
Reaction notes
Loading…