Dichloromethane → HCID 118432072, compound

Participants

Reaction Steps

1-(2-Chloro-phenyl)-5-[4-(1,2,3,6-tetrahydropyridin-4-yl)-phenyl]-3-[di-(trifluoromethyl)-hydroxy-methyl]-4,5-dihydro-1H-pyrazole trifluoroacetate (15.0 mg, 0.02 mmol) prepared in Example 292, triethylamine (9.3 uL, 0.07 mmol) and acetyl chloride (3.6 uL, 0.03 mmol) were added at 0° C. to dichloromethane (1.0 mL). The reaction mixture was stirred at room temperature for 2 hours and then distilled water was added thereto. The reaction mixture was extracted with dichloromethane two times. The combined extract was washed with 1N hydrochloric acid, a saturated solution of sodium carbonate, and brine, dried on anhydrous magnesium sulfate, and then concentrated under reduced pressure to give a yellow liquid residue. The resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/3) to give 4.9 mg of the titled compound as a yellow liquid.

Provenance & Evidence